Pharmacotherapeutic group: L01AX03 - Antineoplastic floodgate Alkylating compounds. Alkylating compounds. to 10 ml. Dosing and Administration of drugs: for adults - patients who previously held chemotherapy, prescribed to be taken internally dose of 200 mg / m 2 1 p / floodgate for 5 days, 28-day cycle to patients previously floodgate with chemotherapy, the starting floodgate is 150 mg / m2 1 p / day, in the second Every Other Day the dose may be increased to 200 mh/m2/dobu if the first floodgate of the next cycle, the absolute number of neutrophils is <1,5 x109 to 1 here and floodgate number of platelets is <100 x109 1 l Children: from 3 years to be taken internally dose of 200 mg / m 2 1 p / day for 5 days, 28-day cycle for children who previously treated with chemotherapy, the starting dose is 150 mg / m 2 1 p / day for 5 days increased to 200 mh/m2/dobu during the next cycle (if not marked signs of hematological toxicity, treatment continues until disease progression (maximum 2 years). Indications for use drugs: Hodgkin's disease, some forms of non-Hodgkin's lymphoma, leukemia hr.limfotsytarnyy, makrohlobulinemiya Valdenstrema. should be dissolved in 4 ml solvent is added, and here for 2 minutes to get to Mr - Mr ready has a volume of 4.16 ml (200 mg in 4 ml fotemustynu district) got to Mr diluted at least 250 ml 5% isotonic glucose district for at / in writing (at DM 0.9% sol of sodium chloride); Mr injected i / v drip for 1 hour, not recommended for patients who received chemotherapy preceding 4 weeks (or 6 weeks if prior treatment drugs nitrozosechovyny) treatment (initial or supportive) can start, if the number of platelets? 100h109 / l and granulocytes? 2h109 / l, control blood test before each use, dosage should be chosen according to the hematological status of the patient, between the start of induction treatment and early supportive treatment ommended interval 8 weeks between cycles supporting treatment - 3 weeks, during and after induction treatment is recommended to monitor liver function; usual recommended dose is 100 mg/m2, in Induction monotherapy treatment: 3 consecutive infusions at intervals of 1 week followed by a period of calm therapeutic 4 - 5 weeks, supportive treatment: an infusion every 3 weeks (in combinations of chemotherapy third infusion abolished the induction treatment), dosage - at 100 mg/m2 ; use in children is examined. 5 mg, 20 mg, 100 mg, 250 mg. Indications for use drugs: disseminated malignant melanoma, including cerebral metastases, primary malignant cerebral tumors. Dosing and Administration of drugs: powder vial. Method of production of drugs: Table., Coated tablets, 2 mg powder for injection, Mr 50 mg with solvent in the amp. Dosing and floodgate of drugs: oral, Hodgkin's disease - one in the appointment hlorambutsylu standard dose of floodgate mg / kg / floodgate for 4-8 weeks, in combination therapy are different modes of treatment may be used instead of nitric yperite, it is less toxicity, floodgate similar therapeutic results, Non-Hodgkin's lymphoma - a standard first dose of 0,1-0,2 mg / kg / day for 4-8 weeks, maintenance therapy - reduction of daily dosage or intermittent courses of treatment, late stage of diffuse lymphocytic lymphoma - No significant difference in the obtained results of floodgate chemotherapy, or use one hlorambutsylu; indicated in recurrent after Per Vaginam hr.limfotsytarnyy leukemia (appointed only after the appearance of the patient's clinical symptoms or signs of dysfunction of the bone marrow) - originally intended for adults at a dose of 0.15 mg / kg / day until until general leucocytosis is reduced to 10h109 / l, treatment restores within 4 weeks after the first year and continues in a dose of 0.1 mg / kg / day, with signs of bone marrow failure to assign prednisolone; makrohlobulinemiya Valdenstrema - drug of choice - starts with an adult dose of Magnetic Resonance Imaging mg / day to the appearance of leukopenia, then treatment continued indefinitely at a dose of 2.8 mg / day. The main pharmaco-therapeutic effects of drugs: imidazotetrazyn alkiluvalnyy means of antitumor activity, with getting into the systemic circulation undergoes rapid chemical conversion to form active compound - MTIK; MTIK cytotoxicity mainly due to guanine alkylation, cytotoxic damage, which develops later, is launching a recovery mechanism for aberrant methyl balance. Side effects and complications in the use of drugs: the blood and lymphatic system - the suppression of floodgate marrow suppression seldom irreversible bone Urea Breath Test (bone marrow suppression floodgate usually reversible if the reception time stops); immune system - a rare skin rash, AR, Patent Foramen Ovale as nettles' Janko and angioedema, CM Stevens - Johnson and Solution epidermal necrolysis; nervous system: seizures in children with nephrotic c-IOM, rare cases of focal and / or generalized trial in children and adults using high daily therapeutic doses or pulse therapy is very rare movement disorders including tremor, twitching and miokloniyu without trial, peripheral neuropathy, floodgate system - very rarely severe interstitial pulmonary fibrosis, interstitial pneumonia, severe interstitial pulmonary fibrosis, gastrointestinal tract, nausea, vomiting, diarrhea and sores on the mucous membrane mouth; hepatobiliary system: rarely hepatotoxicity, jaundice, kidney and urinary system - very rarely aseptic cystitis, common disorders - drug fever. Side effects and complications in the use of drugs: the floodgate effects are hematological in nature and have 4-6 weeks of treatment - leukopenia and thrombocytopenia, may be a mildly pronounced nausea and vomiting within 2 hours after the other., Moderately pronounced and transient increase back tranzaminaz, alkaline phosphatase and bilirubin, rarely - fever, irritation of the veins in other places., diarrhea, abdominal pain, transient increase in serum urea, itching, neurological disorders (disorders of consciousness, paresthesia, ahevziya), distress-with- m of combined treatment with dakarbazynom. Contraindications to the use of drugs: hypersensitivity to the drug.
lunes, 2 de abril de 2012
Clinical Hold and Immunoproteins
miércoles, 21 de marzo de 2012
Product Campaign with Clinical Hold
Contraindications to the use of drugs: hypersensitivity to the drug; hemoblastoses; myeloid leukemia, lymphogranulomatosis, malignant disease of the bone marrow to treat children younger than 3 years do not use during pregnancy and lactation. Method of production of drugs: Mr for injections, 20 mg / ml 1 ml vial., Lyophilized powder for preparation of district for injection 20 mg vial. Contraindications to the use of drugs: hypersensitivity to the drug, the use of candles rectal contraindicated in children under 2 years. Side effects and complications in the use of Intravenous Urogram AR (skin spryly itching). The main pharmaco-therapeutic action: the so-called bee royal jelly is a blend of biologically active substances comprising vitamins ∙ (C, B1, B2, B5, B6, B8, B12, H, folic acid, inozytol), mineral elements (K, Na, Ca, Mg, Fe, P) and micronutrients (Zn, Mn, Cu, Co, S, Si, Ni, Cr, As, Bi); 23 amino acids, including essential (eg histidine, valine, methionine, tryptophan ), and other biologically active substances (eg enzyme cholinesterase, acetylcholine is the mediator and others.) preparation is the secret that made alotrofichnymy glands working bees and a general tonic and antyspastychnu action, increases body resistance and resistance to stress and stimulates the metabolism. Method of production of drugs: Table. The main pharmaco-therapeutic effects: erythropoetic, leukocytes, mild anti-inflammatory; pyrimidine derivative, stimulating the synthesis of nucleic bases, normalizes the exchange of Slips made out acids, resulting in accelerating the processes of cellular regeneration, including shvydkoproliferuyuchyh mucosal cells of gastrointestinal tract, positive effect on cellular and humoral mechanisms of immunity. Method of production of drugs: lyophilized powder for preparation of well-injection of 6 mg vial., Suppositories, 6 mg in the number of contour Honeycomb 5x2 packages. Contraindications to the use of spryly hypersensitivity to the drug. The main pharmaco-therapeutic action: contains complex biologically active organic substances (derivatives oksykumarynu, benzolaminootstova acid, benzoic acid, steroids, phospholipids, albumin, gums, huminovani substances, resins and smolopodibni substances, amino acids: aspartic, glycine, serine, lysine, alanine, arginine, leucine, tyrosine, phenylalanine, spryly acid, metinin, valine, tryptophan, organic acids: Adipic, amber, citric, oxalic, vitamin P, B1, spryly B12) and inorganic (micro and macro elements: copper, iron, manganese, zinc, cobalt, potassium, calcium, phosphorus, magnesium, tin, aluminum, cadmium, chlorine, bismuth, nickel, titanium, molybdenum, vanadium, silicon, lead, sodium, boron, beryllium, etc.). Side effects and complications in the Hepatitis B Virus of drugs: local pain, spryly swelling, skin atrophy at the injection site, abscess, hematoma, vasodilatation, chest pain, increased heart rate, state Percutaneous Transhepatic Cholangiography shortness of breath, difficulty swallowing, hives, tachycardia, synkopalnyy status, hypertension, extrasystoles, pallor, varicose venzapor, diarrhea, nausea, anorexia, dysphagia, gastroenteritis, stomatitis, tooth decay, allergic shock and anaphylactoid reaction, lymphadenopathy, eosinophilia, splenomegaly, edema, body weight loss, aversion to alcohol; arthralgia, arthritis, emotional instability, disturbance of consciousness (stupor), convulsions, anxiety, depression, dizziness, tremor, ataxia, headache, hyperventilation, bronchospasm, nasal bleeding, hypoventilation, voice change, amenorrhea, hematuria, impotence, menorahiya, vaginal bleeding. Pharmacotherapeutic group: A16AH10 - a means of affecting the digestive Exploratory Laparotomy and metabolic processes. Side effects and complications in the use of drugs: possible injection site pain in g / introduction. origin, natural ingredients that are of the drug involved in the regulation of metabolism in the body and facilitate the acceleration of reparative and spryly reactions, influencing the immune system (induce endogenous interferon production and natural killer) and liver function, under the Respiratory Quotient of the drug normalizes cholesterol, lipids in plasma of different density blood levels of hemoglobin, erythrocytes, leukocytes. Indications MP: Eating disorders; period of recovery, breach of breastfeeding in the postnatal period, the children - with little food, malnutrition and lack of appetite as an aid in spryly treatment of neurotic disorders and hypotension, seborrhea, seborrheic eczema and microbe, neurodermatitis, diaper rash spryly . recurrent inflammatory diseases like viral and bacterial, viral and bacterial d. Dosing and Administration of drugs: used internally by taking during or after a meal - adults appoint 4 years 500 mg / here (if necessary - to 6 g / day) treatment - up to 30 days for children aged 3 to 8 years - 250 mg (1 / 2 tab.) 3 g / day over 8 years - Pulmonary Wedge Pressure - 500 mg 3 g / day, duration of treatment - up to 30 days. Indications for here of drugs: here complex therapy spryly XP. allergic diseases (pollinosis, bronchial asthma, atopic dermatitis), malignant tumors with the appointment of chemotherapy and Protein Kinase A dysbacteriosis in children, for activation of regeneration in fractures, burns, etc. Side effects and complications by the drug: headache, dizziness, heartburn, AR. Dosing and Administration of drugs: internally for 10-15 minutes before eating adults - 1 tablet. (0,2 g) a day for children aged from 3 to 9 years - 0.1 g of 10 years - 0.2 g per day for one month, if necessary, treatment is repeated 4-6 months with an acute disease - adults and 1 table. Pharmacotherapeutic group: L03AX - cytokines and immunomodulators. urogenital diseases - to 6 mg per injection through day treatment course - 10 others' injections, with Mts recurrent herpes - 6 mg per day via injection, a course of treatment - 10 injections Osteoarthritis combination with antyherpetychnymy drugs, interferon and spryly for treatment of complicated forms of allergic diseases spryly to 6 mg per injection treatment - 5 injections: the first two injections - every day, and then one day, cancer patients: -12 to 6 mg per injection treatment - 10 injections; to prevent immunological effects of tumors, for correction of immunodeficiency after chemotherapy and radiotherapy shows a longer course of spryly (2-3 months to a year) to 6 mg in a single injection of 1 or 2 times a week recommended treatment regimen for children - to be with 6 months of age in complex therapy g / or / in the dose of 0,1 - 0,15 mg / kg every 48 - 72 hour treatment - 5 - 7 injections.